Research and Development (R & D)

COSMECEUTICALS

At Okoko Cosmétiques, consistently investing and pursuing R & D is one of our core values. The Okoko line was developed and formulated by skincare formulator and researcher Oyéta Kokoroko. In collaboration with our team of passionate skincare formulators, we pride ourselves on offering evidence-based products in luxurious formulations that work to reveal more youthful, smooth and luminous skin appearance.

We dedicate extensive hours doing R & D to come up with amazingly effective products that are exciting, luxurious and elegant, and formulas that are based on customers needs, feedback and concerns. As a result, our evidence-based formulations deliver exceptional results.

At Okoko Cosmétiques, we don’t use gimmicks, unnecessary ingredients or exaggerated claims to make marketing statements. We research the best high-performance ingredients and concentrations to create superior formulations for a wide range of skin look concerns. You can find below some references and research conducted by various scientists and medical doctors for some of Okoko Cosmétiques favorite ingredients.

It is very important to understand that, even when we like to create awareness for a better skin health, this content is shared for educational purpose only and is not intended to diagnose, treat, cure,
or prevent any disease.

BAKUCHIOL

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
https://www.ncbi.nlm.nih.gov/pubmed/29947134

Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.
https://www.ncbi.nlm.nih.gov/pubmed/24471735

Psoralea corylifolia (Babchi)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249905/

We Asked Dermatologists All About Bakuchiol, A New Retinol Alternative
https://www.more.com/beauty/skincare/anti-aging/we-asked-dermatologists-all-about-bakuchiol-new-retinol-alternative

Anti microbial activity of different dosage forms of Bakuchi (Psoralea corylifolia Linn.) taila, An Ayurvedic formulation
https://ijam.co.in/index.php/ijam/article/download/06292015/318

ALPHA HYDROXY ACIDS (AHAS)

Alpha Hydroxy Acid (AHA) / Beta Hydroxy Acid (BHA)
https://www.naturopathica.com/system/user_files/attachments/6/original/Naturopathica_AHAs.pdf

Anti-Aging Skin Treatments: What Really Works?
https://www.livescience.com/34995-skin-care-anti-aging-creams-100929.html

Topically applied lactic acid increases spontaneous secretion of vascular endothelial growth factor by human reconstructed epidermis.
https://pdfs.semanticscholar.org/d22e/d2a76c3a0ea2206f46141fc82ff2201e6c06.pdf

Clinical role and application of superficial chemical peels in today's practice.
https://www.ncbi.nlm.nih.gov/pubmed/19746672

DRAGON'S BLOOD

Efficacy of Dragon's blood cream on wound healing: A randomized, double-blind, placebo-controlled clinical trial.
https://www.ncbi.nlm.nih.gov/pubmed/26870678

Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation.
https://www.ncbi.nlm.nih.gov/pubmed/8350090

Bioprotective properties of Dragon's blood resin: in vitro evaluation of antioxidant activity and antimicrobial activity.
https://www.ncbi.nlm.nih.gov/pubmed/21329518

Dragon’s Blood Helps Wound Healing & Skin Care (+ More Dragon’s Blood Benefits)
https://draxe.com/dragons-blood/

Dragon's blood: Botany, chemistry and therapeutic uses
https://www.ncbi.nlm.nih.gov/pubmed/18060708

Polyphenolic compounds from Croton lechleri
https://www.sciencedirect.com/science/article/abs/pii/0031942291850636

Plant Biology of Croton lechleri
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202292Orig1s000BotanicalR.pdf

Dragon’s blood secretion and its ecological significance
Red latex/resin as a plant defence strategy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863904/

NIACINAMIDE

Niacinamide: A B vitamin that improves aging facial skin appearance.
https://www.ncbi.nlm.nih.gov/pubmed/16029679

The effect of 2% niacinamide on facial sebum production.
https://www.ncbi.nlm.nih.gov/pubmed/16766489

Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin
https://www.ncbi.nlm.nih.gov/pubmed/18492135

Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
https://www.ncbi.nlm.nih.gov/pubmed/19017042

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation
https://www.ncbi.nlm.nih.gov/pubmed/31141852

Evolution of the use of antioxidants in anti-aging cosmetics.
https://www.ncbi.nlm.nih.gov/pubmed/31220359

Oily Skin: A review of Treatment Options.
https://www.ncbi.nlm.nih.gov/pubmed/28979664

Niacinamide - mechanisms of action and its topical use in dermatology.
https://www.ncbi.nlm.nih.gov/pubmed/24993939

Management of Hyperpigmentation in Darker Racial Ethnic Groups
https://scmsjournal.com/article/buy_now/?id=242

ACETYL-GLUCOSAMINE

Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine.
https://www.ncbi.nlm.nih.gov/pubmed/17348991

New studies show topical glucosamine targets pigment overproduction
https://www.eurekalert.org/pub_releases/2006-03/msl-nss032306.php

Improved appearance of facial hyperpigmentation with use of a cosmetic moisturizer containing N-acetyl glucosamine and niacinamide.
https://www.jaad.org/article/S0190-9622(14)00104-2/fulltext

Natural options for the management of hyperpigmentation.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1468-3083.2011.04130.x

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/19845667.

VITAMIN C & E

Interaction of vitamins C and E as better cosmeceuticals.
https://www.ncbi.nlm.nih.gov/pubmed/18045356

Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions.
https://www.ncbi.nlm.nih.gov/pubmed/16029672

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non-invasive methods.
https://www.ncbi.nlm.nih.gov/pubmed/19159387

TOPICAL VITAMIN C AND THE SKIN: MECHANISMS OF ACTION AND CLINICAL APPLICATIONS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/pdf/jcad_10_7_14.pdf

CO-ENZYME Q10 (UBIQUINONE)

Topical treatment with coenzyme Q10‐containing formulas improves skin's Q10 level and provides antioxidative effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737275/

The Anti-Aging Power of Topical Vitamins
https://www.happi.com/issues/2014-02-01/view_anti-aging--cosmeceutical_corner/the-anti-aging-power-of-topical-vitamins

The role of cosmeceuticals in antiaging therapy.
https://pdfs.semanticscholar.org/b494/302b13b9fb5067472f48d8319ff97d8ee41f.pdf

The Role of Cosmeceuticals in Antiaging Therapy
http://www.novaq10cosmetics.com/pdf/cosmetics/cosmetics-studies1.pdf